Expression and clinical significance of Ikaros6 isoform in adult T-cell acute lymphoblastic leukemia patients
10.3760/cma.j.issn.1009-9921.2014.02.007
- VernacularTitle:成年人T细胞急性淋巴细胞白血病中Ikaros6表达及其临床意义
- Author:
Na ZHANG
;
Ya'nan LIU
;
Xiaoyi DING
;
Jianfeng ZHOU
;
Chunrui LI
;
Min XIAO
;
- Publication Type:Journal Article
- Keywords:
Adult;
T-cell acute lymphoblastic leukemia;
Ikaros6;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2014;23(2):84-87,91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and prognostic value of Ikaros6 in adult T-cell acute lymphoblastic leukemia(T-ALL) patients.Methods The RNA was extracted from mononuclear cells of bone marrow in 74 adult T-ALL patients.The expression of Ikaros6 was examined by reverse transcription-PCR,and the results were confirmed by sequencing.Clinical features and prognosis were analyzed based on clinical data.Results In 74 T-ALL patients,the incidence rate of Ikaros6 was 21.6 ％ (16/74).Extramedullary infiltrations were occurred often (x2 =4.084,P =0.043),had higher WBC (103.15 × 109/L vs 15.60×109/L,t =0.214,P =0.831),more severe anemia (75.95 g/L vs 107.00 g/L,t =1.504,P =0.142) and lower platelet count (26.0×109/L vs 67.0×109/L,t =1.421,P =0.164) in patients with Ikaros6 positive.Meanwhile Ikaros6-positive patients had inferior survival and were increased risk of relapse as compared with the Ikaros6-negative patients.Conclusions The incidence of Ikaros6 is high in adult T-ALL patients.Ikaros6-positive patients are more likely to have extramedullary infiltration and higher WBC,meanwhile they had inferior survival and increased risk of relapse.Thus Ikaros6 may be served as a valuable factor for risk stratification and prognosis evaluation in adult T-ALL patients.
