Expression of Survivin and hypoxia inducible factor-1α in prostatic carcinoma and their correlations
10.3760/cma.j.issn.1006-9801.2014.01.010
- VernacularTitle:凋亡抑制蛋白Survivin和缺氧诱导因子-1α在前列腺癌中的表达及其相关性
- Author:
Jiewen LIU
;
Xi'an LU
;
Lifen HAO
;
Guangqiang QI
;
Yang LEI
;
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Survivin;
Hypoxia inducible factor-1α
- From:
Cancer Research and Clinic
2014;26(1):36-38,41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of Survivin and hypoxia inducible factor-1α (HIF-1α) in prostatic hyperplasia and prostatic carcinoma,and investigate their roles and mutual correlations in pathogenesis and progression of prostatic carcinoma.Methods The expression of Survivin and HIF-1α in proliferative lesions of prostate (15 cases) and prostatic carcinoma (62 cases) were detected by immunohistochemistry method.The relationship between the expressions of Survivin and HIF-1α was analyzed,as well as their correlations with clinicopathological features.Results The positive expression of Survivin and HIF-1α were significantly higher in the prostatic carcinoma [71.0 ％ (44/62) and 69.4 ％ (43/62),respectively] compared with those of the prostatic proliferation [6.7 ％ (1/15) and 0] (x2 =20.56,P 0.001; x2 =23.56,P =0.001,respectively).The expression of Survivin and HIF-1α in prostate carcinoma was significantly related with the histological grading,clinical staging (x2 =10.64,5.39,7.62,6.43,all P ＜ 0.05).And there was positively correlated between Survivin and HIF-lα (rs =0.350,P =0.006).Conclusion Survivin and HIF-1α synergistically play important roles in pathogenesis and progression of prostatic carcinoma.
