Clinical observation on effect of biological agent etanercept cmbined with methotrexate in treatment of refractory rheumatoid arthritis

VernacularTitle:生物制剂益赛普联合甲氨蝶呤治疗难治性类风湿关节炎的疗效观察
Author: Wang SHAN ;
Publication Type:Journal Article
Keywords: arthritis,rheumatiod; etanercept; methotrexate
From: Chongqing Medicine 2013;(26):3100-3101,3104
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical effect of biological agents etanercept combined with methotrexate in the treat-ment of refractory rheumatoid arthritis .Methods 30 cases of refractory rheumatoid arthritis treated in January 2010 to January 2012 were selected and randomly divided into the two groups ,15 cases in each group .The control group was treated with oral meth-otrexate(MTX) 15 mg per week ,and the combined treatment group was treated with the biological agent etanercept 12 .5-25 .0 mg by subcutaneous injection ,twice per week ,combined with M TX15 mg per week .3 months were taken as a course of treatment .Re-sults The effective rates of ACR20 ,ACR50 and ACR70 in the combined treatment group were 73 .3% ,46 .7% and 26 .7% respec-tively ,which were significantly higher than those in the control group (P<0 .01) .4 cases in the combined treatment group appeared gastrointestinal discomfort .Conclusion Biological agent etanercept combined with M TX in the treatment of refractory rheumatoid arthritis has better clinical curative effect .