Expression of p16 and p15 Proteins in Acute Lymphoblastic Leukemia of Children
- VernacularTitle:p16、p15蛋白在小儿急性淋巴细胞白血病的表达及临床相关性研究
- Author:
Wanru HU
;
Ruiying ZHANG
;
Chengji GUO
;
Li'E WANG
;
Shuyan DU
;
- Publication Type:Journal Article
- From:
Journal of China Medical University
2001;30(1):64-65,68
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Our aim was to To clarify the roles of p16 and p15 proteins in the genesis of acute lymphoblastic leukemia(ALL).Methods:Twenty-three samples of ALL were studied by the method of indirect immunofluorescence.Flow cytometer was used to estimate the cellular fluorescent intensity to determine the levels of p16 and p15 proteins.Results:Negative expression for p16 protein was found in 10 of 23 samples,and 8 of 23 were p15 negative expression.Both kinds of proteins were abscent in 6 samples.2 of 3 cases of T-ALL were negative expression of p16,p15 protein.In non T-ALL,6 of 13 were negative expression for p16 protein,5 of 13 were p15 protein deficient.The expression rates of p16,p15 protein in high leukocyte group were lower than those of non-high leukocyte group(P<0.05).The expression rates of p16,p15 proteins in HR-ALL were lower than those of SR-ALL(P<0.05).Conclusion:The p16 and p15 proteins take part in the genesis of ALL.Negative expression of p16,p15 proteins might imply the poor clinical outcome.
