The feeding behavior of cross-intestine parabiotic rats are modulated by brain histamine
- Author:
H.Noguchi
;
H.KoopmansH
;
Tanaka
;
T.Fukagawa
;
K.Goto
;
K.Fukagawa
;
H.Yoshimatsu
;
T.Sakata
- Publication Type:Journal Article
- From:
Chinese Journal of Pathophysiology
2001;17(8):776-
- CountryChina
- Language:Chinese
-
Abstract:
To clarify the mechanism in which signals to regulate food intake are transmitted from the gastro-intestinal system to the brain, we analyzed changes in hypothalamic neuronal histamine using cross-intestine parabiotic rats. Pairs of weight matched Lewis rats were sewn together in such a way as to form a common abdominal cavity. The small intestines of rats were transected and reconnected so that food eaten by one rat passed through a segment of its partner's intestine before returning to the intestine of the first rat. Concentrations of neuronal histamine were measured in microdissected hypothalami using radioimmnoassay. Sustained alteration of food intake were observed in both rats, one rat eating an average of 2.2 times (SE 0.15) as much as the other, without development of any significant difference in body weight after seven weeks. We found significant increase in hypothalamic neuronal histamine concentrations in the arcuate and tublomamelary nuclei of the hypophagic rats.These results are supportive of the theory that histamine acts in response to signals from the gut to regulate food intake.
