The variance of HSP70 in cardiac cells of SMDS victims
- VernacularTitle:HSP70在青壮年猝死综合征心肌组织中的变化
- Author:
Jiquan YAN
;
Hualan JING
;
Yijun ZHANG
;
Hongquan XU
;
Yongxi WEN
;
Hong LIN
;
Fuxue JIANG
;
Tianyu LU
;
- Publication Type:Journal Article
- Keywords:
forensic pathology;
Hsfr70;
SMDS;
immunohistochemical staining
- From:
Chinese Journal of Forensic Medicine
2009;24(6):394-396,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective This article aims to explore the role of HSP70 in the developing mechanism of SMDS(sudden manhood death syndrome,SMDS)and to investigate the value of it in the early diagnosis of SMDS.Methods By way of immunohistochemieal staining of left,right ventricular musles,sino atrial node and atrioventricular node from 30 cases of SMDS group and 20 cases of control group,we observed and measured the expression of HSP70 and its variance of intensity with graphical analysis software.Results Compared with the control group cases,in cardiac conduction system tissue of SMDS victims.we saw an obviously higher expression and intensity of HSP70(P<0.05).Conclusion As a kind of mediator in stress reaction,HSP70 is involved in the process of protecting the heart from impairment in SMDS,and it can be considerated as a reference index to identify the SMDS.
