Bacteriophage Lysins:A Novel Effective Antibacterial Agents
- VernacularTitle:噬菌体裂解酶——现状与未来
- Author:
Yuan-Zi FANG
;
Yan WANG
;
Jian-He SUN
;
- Publication Type:Journal Article
- Keywords:
Bacteriophage, Lysin
- From:
Microbiology
2008;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Lysins are efficient bacteria cell wall digesting enzymes encoded by DNA bacteriophage. Gram-positive bacteriophage lysins feature similar domain structure, high lytic efficiency, synergic antibacterial effect with antibiotics, rare neutralization by antibodies, less chance of developing drug-resistant strains, et al. The past decade has seen a considerable amount of research worldwidely focused on lysin, and lysins have been used successfully in a variety of animal models to control pathogenic antibiotic resistant bacteria found on mucosal surfaces and infected tissues. The great potential of lysins as an anti-infective agent prompted this review.
