Hemodynamic changes following cerebrovascular stenting
- VernacularTitle:脑血管支架置入后的血流动力学变化
- Author:
Na-Xin LI
;
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
Intravascular stent as a foreign body induces platelet-monocyte aggregation following implantation, mediates various actions of monocyte, induces monocyte to express tissue factors, promotes fibrin sedimentation at injury site, and accelerates inflammatory reaction of vessel wall injury. In addition, it stimulates platelet aggregation on the stent, activates platelet system and coagulation system, resulting thrombosis. Smooth muscle cells migration to injury site, neointima hyperplasia, and vessel wall reconstruction cause in-stent restenosis. The influential factors that induce restenosis include type of stent, original diseases of the host, stenosis severity before stenting and residual stenosis length after stenting. Inhibition of tunica intima hyperplasia or improvement of neointima as well as vessel wall reconstruction could effectively prevent restenosis.
