Cushing's Disease: The Diagnostic Value of Radiologic Studies.
10.3348/jkrs.1995.32.3.363
- Author:
Hee Won JUNG
;
Moon Hee HAN
;
Kee Hyun CHANG
;
Jae Uoo SONG
;
Yoong Ki JEONG
;
Cheol Soo SEO
- Publication Type:Original Article
- MeSH:
ACTH-Secreting Pituitary Adenoma;
Diagnosis;
Female;
Humans;
Pituitary Gland;
Retrospective Studies
- From:Journal of the Korean Radiological Society
1995;32(3):363-367
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the diagnostic value of radiologic studies in the Cushing's disease MATERIALS AND METHODS: We analyzed retrospectively the CT(n=19, dynamic CT was not perfomed), MR (n=23, dynamic MR in 2 cases), and the results of inferior petrosal sinus sampling(IPSS)(n=13) in 25 patients(19 women, 6men, age range 16-58, mean 32.2) with pathologically-confirmed ACTH secreting pituitary adenoma. We analyzed the radiologic findings and determined how accurately each method could detect and lateralize the lesion within the pituitary gland. The results were compared with the surgical findings and with each other. RESULTS: Seven patients(28%) out of 25 had macroadenomas and the lesions were detected and correctly diagnosed by CT and MR in all. Eighteen patients(72%) had microadenoma. In patients with microadenoma the sensitivity was 38.5%(5/13) in CT, 64.7%(11/17) in MR, 90.9%(10/11) in IPSS. In two patients with dynamic MR, in whom the conventional Gd-enhanced MR showed false negative results, the lesions were detected as low signal intensity mass and correctly lateralized. Considering the results of both MR and IPSS, the sensitivity increased up to 94.1%(17/18). CONCLUSION: Considering the invasiveness of IPSS, Gd-enhanced MR, preferably dynamic, seems to be an imaging modality of choice in Cushing's disease. Combined use of IPSS in selected patients further increases the accuracy of diagnosis and lateralization.
