Current Status and Progress on the Techniques for Prolonging Half-life of Protein Pharmaceuticals
- VernacularTitle:蛋白质药物长效化技术的现状和进展
- Author:
Lei BIAN
;
Yi-Feng SHI
;
- Publication Type:Journal Article
- Keywords:
Chemical modification Protein fusion Microsphere Glycosylation Protease-resistant variants
- From:
China Biotechnology
2006;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The latest developments of techniques that prolong the half-life of protein drugs were reviewed.The therapeutic potential of several proteins is limited by their rapid clearance from the body,resulting in the need for frequent treatment of individuals to maintain drug levels.Several techniques including chemical modification,protein fusion,microsphere,glycosylation,and protease-resistant variants,and so on,prevent rapid degradation of such drugs and prolong their half-lives in vivo.Several successful protein drugs with prolonged half-life have already been on the market or on clinical trials.The principles,efficiencies and scopes of application of these techniques were described,compared and discussed.
