Antimicrobial Peptides: Antibacterial Mechanism and Therapeutic Use
- VernacularTitle:抗菌肽的抗菌机制及其临床应用
- Author:
Xiao-Shu HOU
;
Zong-Li HU
;
Guo-Ping CHEN
;
Yong LI
;
Bing-Qin WANG
;
Zhi-En LI
;
- Publication Type:Journal Article
- Keywords:
Antibacterial peptides, Mechanism of antibiosis, Clinical application
- From:
Microbiology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial peptides, a cluster of small peptides secreted by the majority of creatures, have been demonstrated with activity against a wide range of microorganisms including bacteria, protozoa, yeast, fungi, viruses and even tumor cells. These peptides have some features such as broad spectrum , high effi-cacy and stability, little drug resistance. A lack of new antibiotics combined with emerging multi-drug resis-tance issues demands that new antimicrobial strategies be explored for treating these infections. It has been proposed that the antimicrobial peptides might form the foundation for a new class of clinically useful an-timicrobials. We review the advantages of these molecules in construction features and bioactivity, with the focus on the mechanism and clinical applications.
