Progress and Insight of miRNA on Hepatocellular Carcinoma
- VernacularTitle:miRNA在肝细胞癌中的研究进展
- Author:
Peng QI
;
Chun-Fang GAO
;
- Publication Type:Journal Article
- Keywords:
MicroRNAs Hepatocellular carcinoma Diagnosis Biotherapy
- From:
China Biotechnology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs(miRNAs) are endogenous non-coding RNAs,about 20 nucleotides in length.They play a pivotal role in the regulation of genes involved in diverse biology processes such as cell development,proliferation,differentiation and apoptosis by the translation repression or mRNA degradation.Recent evidence has suggested that miRNA alterations are involved in the initiation and progression of various human cancer including hepatocellular carcinoma(HCC),and miRNA-expression profiling of HCC has identified signatures associated with diagnosis,staging,progression and prognosis.As a novel molecular target,miRNAs holds great promise in diagnosis and biotherapy of HCC.
