Relationship Between the Angiotensin-Converting Enzyme 2 Genotype and Effect of Irbesartan on Left Ventricular Structure and Function in Hypertensive Patients
- VernacularTitle:血管紧张素转换酶2基因型与厄贝沙坦改善高血压患者左室重构及功能的关系
- Author:
Cao-Jin ZHANG
;
Fu-Rong CHEN
;
Zhi-Xin SHAN
;
Yong-Heng FU
;
Wen-Jun YI
;
Dong-Li CHEN
;
- Publication Type:Journal Article
- Keywords:
Angiotensin converting enzyme 2;
Gene polymorphisms;
Essential hypertension;
Left ventricular structure;
Left ventricular function
- From:
Chinese Journal of Hypertension
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Background Experimental data have shown tnat polymorpnisms in tne angiotensm-converting en- zyme 2(ACE2)gene are related to echocardiographically determined parameters of left ventricular mass,structure or function in the general population whether ACE2 genotype influences the effect of angi0tensin Ⅱ receptor blocker which improve left ventricular remodeling and function is unknown.Objective To investigate the association be- tween ACE2 gene G9570A polymorphism and the effect of irbesartan on left ventricular structure and function in hy- pertensive patients.Methods Two hundred and five male patients and 190 female patients who were preliminaryly diagnosised with mild and moderate essential hypertension were treated with irbesartan for 48 weeks with initial dose of 150 mg/d and titrated to 300 mg/d to reach the targed BP.Gene polymorphisms of ACE2 G9570A were detected by PCR-RFLP methods.The association between changes in the SBP,DBP,parameters of left ventricular struc- ture and function and genotypes of the ACE2 gene locus were analyzed.Results Irbesartan reducted in blood pres- sure in all patients(P
