Effect of Endothelial Progenitor Cell Transplantation on Pulmonary Hypertension in Rats
- VernacularTitle:内皮祖细胞移植对肺动脉高压大鼠血流动力学及肺血管结构的影响
- Author:
Lian-Man HE
;
Jun HUANG
;
Jing XIAO
;
Jun-Fang WU
;
- Publication Type:Journal Article
- Keywords:
Endothelial progenitor cell;
Monocrotaline;
Pulmonary artery hypertension;
Cell transplantation
- From:
Chinese Journal of Hypertension
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the hemodynamics and structural effect of rat endothelial progenitor cells (EPC) transplant on pulmonary artery hypertension (PAH) induced by monocrotaline(MCT) in rats.Methods EPCs were identified and marked.Twenty-one days after injection of EPCs,the pulmonary hemodynamic parame- ters,average pulmonary artery pressure (mPAP),right heart index were determined.The vascular endothelial cells and pulmonary vascular structural changes were verified by fluoresccuse microscope.Results Compared with the model,EPCs treatment(n=10) decreased mPAP significantly (mPAP,EPCs:25.9?0.7 mmHg vs model group:29.3?2.2 mmHg,P
