Recent Research on CCR5 and Its Antagonists
- VernacularTitle:CCR5及其拮抗剂的研究进展
- Author:
Ying-Ping WU
;
Wen-Yan WU
;
- Publication Type:Journal Article
- Keywords:
CCR5 Antagonists Chemokine receptor
- From:
China Biotechnology
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Chemokine receptor 5 (CCR5 ),as a member of the G protein-coupled receptor(GPCR)superfamily,is a membrane protein on cell surface and one of the major of coreceptors for HIV-1infection.CCR5 has became a molecular target for the novel drugs against HIV-1,and antagonists for CCR5 could be grouped as following, chemokine derivatives,small molecule non-peptide compounds,molecular antibodies and peptides. These compounds with high anti-viral activity and affinity are at different stages, and some have been under clinical studies. Therefore, the development research in the different kind of CCR5 antagonists is reviewed.
