The Short Term Effect of Glutathione on Anti-Oxidative Stress in Patients with Coronary Heart Disease
- VernacularTitle:还原型谷胱甘肽对冠心病患者抗氧化应激的短期效果
- Author:
Yan ZENG
;
Zhi-Jun GUO
;
Chao WANG
;
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Glutathione;
Malondialdehyde;
Superoxide dismutase;
Nitric oxide
- From:
Chinese Journal of Hypertension
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the therapeutical effect of glutathione(GL),a powerful antioxidant on the symptoms and ECG in patients with coronary heart disease and its mechanisms.Methods Eighty-five subjects with coronary heart disease were recruited(45 male and 40 female).The patients were randomized to receive GL (240 mg,ivgtt,qd,for 14 days,n=44)on the top of conventional treatment(aspirin+?-blocks+ACEI)or conven- tional treatement alone(control,n=41).The serum MDA,SOD,NO levels were determined.Electrocardio- graphy(ST stage,T wave)was examined.Results GL significantly improved clinical symptoms scores(2.0+0.5 vs control:1.5+0.5,P
