Effect of Autologous Blood Transfusion on Postoperative Levels of IL-6,IFN-?,and TNF-? after Spinal Operation
- VernacularTitle:自体血液回输对脊柱手术患者术后IL-6、IFN-?和TNF-?的影响
- Author:
Hongfei WU
;
Shuiqing LI
;
Jun WANG
;
- Publication Type:Journal Article
- Keywords:
Autologous transfusion;
Allogeneic transfusion;
Interleukin 6;
Interferon alpha;
Tumor necrosis factor alpha
- From:
Chinese Journal of Minimally Invasive Surgery
2005;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effect of allogeneic and autologous blood transfusion on postoperative immunoreaction in patients after spinal surgeries.Methods A total of 44 patients undergoing spinal operations were randomly divided into two groups.Allogeneic (n=22) or autologous (n=22) buffy-coat-depleted red cells were used in the patients during the operations.The serum levels of IL-6,IFN-?,and TNF-?were determined preoperatively and then re-measured 1 and 7 days after the operations. Results In theautologous group,both IFN-?and IL-6 increased after the oprerations,the level of IL-6 was significantly higher than that in the allogeneic group at days 1 and 7.The concentration of TNF-?did not change after the surgeries in the two groups. Conclusions By autologous blood transfusion,the serum levels of IFN-?and IL-6 can be increased significantly after spinal operation,meanwhile the concentration of TNF-?remains stable.The postoperative inhibitory effect of the procedure on immunocytokines is significantly weaker than that of allogeneic blood transfusion,indicating that autologous blood transfuion can protect or even increase immunofunction after spinal operation.
