Benazepril and Candesartan Attenuate Oxidative Stress in Aorta in Spontaneously Hypertensive Rats
- VernacularTitle:苯那普利与坎地沙坦减轻自发性高血压大鼠主动脉内皮氧化应激
- Author:
Li-Yun YANG
;
Guo-Liang MENG
;
Feng WU
;
Ji-Liang XU
;
Ya-Li REN
;
Jue YU
;
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
P22~(phox);
Active oxygen;
Spontaneously hypertensive rats
- From:
Chinese Journal of Hypertension
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-oxidative stress effects of benazepril and candesartan.Methods SHRs of 12 weeks old were given benazepril(10 mg/kg?d,n=9)or candesartan(4 mg/kg?d,n=9)or combina- tion(Ben:10 mg/kg?d+Can:4 mg/kg?d)for 12 weeks.The tail arterial pressure was measured every two weeks.At end of study,pathological changes in the thoracic aorta,activity of SOD,serum contents of NO and hydroxy radicals,plasma Ang Ⅱ and cGMP,eNOS and P22~(phox)protein expressions in aortic tunica intima were de- termined.Results The thoracic aorta wall was thickened markedly in SHRs,and blood pressure,hydroxy radi- cal,Ang Ⅱ and P22~(phox)protein expression were increased significantly,while the serum NO,level of cGMP and eNOS expression were decreased.Benazepril(Ben)or Candesartan(Can)inhibit the thickening of vessel wall, enhance the activity of SOD(Ben:68.7?2.1,Can:65.6?4.2 vs SHR:48.8?3.2 U/mL,P
