Therapeutic effect of collagen from Cyanea nozakii on adjuvant arthritis in rats
- VernacularTitle:霞水母胶原治疗大鼠佐剂型关节炎的研究
- Author:
Wen-Tao ZHANG
;
Lu-Hong TANG
;
Wei CHEN
;
Dong-Qun CHEN
;
Chao DENG
;
- Publication Type:Journal Article
- Keywords:
Cyanea nozakii;
collagen;
adjuvant arthritis;
antioxidation
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the suppressive effects of collagen from Cyanea nozakii on adjuvant induced arthritis inrat.Methods Rats with adjuvant arthritis received different do- ses of Cyanea nozakii collagen by intragastric administration for two weeks.Incidence and severity of arthritis were assessed by calculation of mean arthritis index,the concentrations of NO,MDA and activity of SOD in the serum were examined.Results Cyanea nozakii colla- gen at different doses could ameliorate the adjuvant induced arthritis,suppress the concen- trations of NO,MDA and increase the activity of SOD in the serum.Conclusion Cyanea noza- kii collagen has therapeutic efficacy in treatment of adjuvant arthritis rats,and the mecha- nism of Cyanea nozakii collagen is probably related to the antioxidation.
