Effects of Simvastatin on Early Oxidative Stress and Caveolin-1 in Apolipoprotein E-Deficient Mice
- VernacularTitle:辛伐他汀减轻载脂蛋白E~(-/-)小鼠氧化应激及小窝蛋白1的表达
- Author:
Dong-Hua YIN
;
Ming GUI
;
Meng LIU
;
Jun HUANG
;
- Publication Type:Journal Article
- Keywords:
Simvastatin;
Apolipoprotein E-deficient mice;
Oxidation stresss;
Caveolin-1
- From:
Chinese Journal of Hypertension
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Background Rare studies on the effect of statin on early stage of atherosclerosis have been repor- ted.Oxidative stress induced endothelial dysfunction may be the initiative factor for the development of atheroscle- rotic plague.Objective To investigate the mechanisms by which simvastatin,prevents atheroselerosis independ- ently of its lipid-lowering effect in Apolipoprotein E deficient mice.Methods Twenty-four 6 week old male apoE- deficient mice were randomly to receive placebo or simvastatin 5 mg/(kg?d)by gavage for 4 weeks.Total choles- terol(TC),super oxide dismutase(SOD),malondialdehyde(MDA)and serum nitric oxide(NO)were measured by biochemical analysis.Endothelium was observed by HE dyeing.The expression of caveolin-1 in aortic wall was detected by immunohistochemistry.Results There was no significant difference in serum TC between control and simvastatin treatment groups.Simvastatin caused less damaged endothelium(33.33% vs control's:75%,P
