Effect of Triple Drugs Combination Therapy Amlodipine,Imidapril,Candesartan on Microalbuminuria in Patients with Type 2 Diabetes Mellitus and Hypertension
- VernacularTitle:3种药物(氨氯地平,坎地沙坦,咪达普利)小剂量联合治疗明显减少高血压糖尿病患者的尿微量白蛋白释出
- Author:
Xin FU
;
Zhen-Wen HUANG
;
Fei-Fei ZHANG
;
Zheng-Bin WANG
;
- Publication Type:Journal Article
- Keywords:
Levoamlodipine;
Candesartan;
Imidapril;
Hypertension;
Microalbuminuria;
Type 2 diabetes rnellitus
- From:
Chinese Journal of Hypertension
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To delineate the speculation that triple combination of small doses of calcium antagonist (levoamlodipine),the ACEI(imidapril)and the ARB(candesartan)may exert more significantly effect on mi- croalbuminuria(MAU)in patients with type 2 diabetes mellitus and hypertension.Methods One hundred sixty ca- ses of consecutive patients with type 2 diabetes mellitus and hypertension were randomized to receive following vari- ous combinations:amlodipine 2.5 mg/candesartan 4 mg(n=40),candesartan 4 mg/imidapril 5 mg(n=40);imidapril 5 mg/amlodipine 2.5 mg(n=40),and amlodipine 2.5 mg/candesartan 4,mg plus imidapril 5 mg(n=40).The changes in blood pressure and MAU were determined before and after treatment.Results Four combinations of treatment all significantly lowered BP(P
