Host-virus Interaction at the miRNA Level
- VernacularTitle:宿主-病毒在miRNA水平上的相互作用
- Author:
Yu-Shu ZHENG
;
Pu ZHAO
;
Bei-Bei JIA
;
Xing-You LIU
;
- Publication Type:Journal Article
- Keywords:
Host, Virus, Interaction, miRNA
- From:
Microbiology
2008;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are recently discovered major regulators of gene expression, which play a pivotal role in a wide spectrum of biological processes including antiviral defence. There is growing evidence that some viruses either encode their own viral miRNAs or subvert cellular miRNAs. The host-and virus-encoded miRNAs and their targets together thus form a novel regulatory layer of interactions between the host and the virus. A better understanding of host-virus interaction mediated by miRNAs would not only enable us to unravel the molecular basis of viral pathogenesis, but also enable us to develop better therapeutic strategies.
