Amine-lyases and Their Applications in Preparation of Pharmaceutical Intermediates
- VernacularTitle:胺基裂解酶及其在医药中间体生产中的应用
- Author:
Bi-Bo HE
;
Xiao-Long CHEN
;
Yu-Guo ZHENG
;
Yin-Chu SHEN
;
- Publication Type:Journal Article
- Keywords:
Amine-lyases, C-N lyases, Validamycin, Monoterpenoid indole alkaloids
- From:
Microbiology
2008;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Carbon-nitrogen lyases (E.C.4.3) are a group of enzymes that release ammonia, amidine or amino group etc, and also show ability to form double bond or ring structure. Specifically, enzymes forming amino group are called amine-lyases (E.C.4.3.3), which are critical in the industrial production of many medicine intermediates. In this review is a summary of four major amine-lyases in terms of their source, enzymatic characteristics and their applications in preparation of pharmaceutical intermediates.
