Endocytosis of Ca Alginate Nanocapsules by Dendritic Cells and Function Induction
- VernacularTitle:树突状细胞对海藻酸钙纳米胶囊的吞噬作用与功能诱导
- Author:
Wei CUI
;
Bing-Qian SHEN
;
Sheng-Li YANG
;
- Publication Type:Journal Article
- Keywords:
Ca alginate nanocapusles Dendritic cells T lymphocytes Adjuvant Cancer immunotherapy
- From:
China Biotechnology
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
The endocytosis/phagocytosis of calcium alginate nanocapsules by peripheral blood derived dendritic cells was confirmed with the use of Quantum dots labeling.Results further demonstrated these nanoparticles could cause the upregulation of HLA-DR expression to induce the maturation of dendritic cells in vitro.Dendritic cells stimulated by nanocapsules covalently loaded with BSA were shown to stimulate the proliferation of self T cells with blank capsules and free BSA as controls,suggesting their potential applications in cancer cell therapy as a new antigen delivery vehicle with a strong adjuvant effect.
