Kynurenine Aminotransferase and Kynurenic Acid in Spontaneous Hypertensive Rats
- VernacularTitle:犬尿氨酸氨基转移酶和犬尿喹啉酸在自发性高血压大鼠中的变化
- Author:
Ning-Ning LI
;
Bing XIAO
;
Yi ZHANG
;
Ding-Liang ZHU
;
Ping GAO
;
- Publication Type:Journal Article
- Keywords:
Spontaneous hypertensive rat;
Kynurenic acid;
Kynurenine;
Kynurenine aminotransferase
- From:
Chinese Journal of Hypertension
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).The concentration of urinary KYNA,metabolite of the KYN,was significantly lower in SHRs compared to WKYs(7.8?1.8 vs 19.9?3.5 ?mol/24 h P=0.013).Both KAT activity in renal cortex and KYNA content in urine were negatively correlated to blood pressure(r=-0.418,P=0.023;r=-0.723,P=0.001).Conclusion The declined activity of KAT in renal cortex and the deficiency of KYNA concentration in urinary may affect blood pressure regulation in SHR by renal metabolite of the KYN.
