Brain White Matter Fiber Change in Major Depression before and after Therapy:a Diffusion Tensor Imaging Study
- VernacularTitle:抑郁症治疗前后脑白质弥散张量成像研究
- Author:
Hai-Yan LIU
;
Zhi-Jian YAO
;
Gao-Jun TENG
;
- Publication Type:Journal Article
- Keywords:
diffusion tensor imaging;
cognitive disorder;
depressive disorder;
treatment
- From:
Chinese Mental Health Journal
2002;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the cognitive function and brain white matter fiber change in major depressive patients prior and post-treatment.Methods:Eleven major depressed patients were given antidepressants for 10 weeks, and their conditions were evaluated using 24-item Hamilton Depression Scale(HAMD).The cognitive function was determined by using Wisconsin Card Sorting Test(WCST),part of Wechsler memory scale and diffusion tensor ima- ging(DTI)was scanned before and after treatment.11 healthy people as control group were involved and given the same tests at the same time.Results:(1)The WCST scores of patients increased significantly after treatment(prior treatment Cc:1.6?1.6,Re:67.9?20.0,Rpe:51.5?24.8;post treatment Ce:4.0?2.1,Re:43.2?18.8,Rpe:22.8?16.0,P=0.001/0.000/0.003).There was no difference in number sequence memory in Wechsler memory scale.No difference was found between patients after treatment and control group in either WCST or number sequence memory.The patients made significant improvement in the total score of HAMD after treatment(16?14/54?13,t=6.60,P
