Recombinant Probiotics for Prevention of Enteric Infections
- VernacularTitle:转基因益生菌:预防肠道感染的新型微生态制剂
- Author:
Yong LIN
;
Wen YAO
;
Wei-Yun ZHU
;
- Publication Type:Journal Article
- Keywords:
Toxins,Recombinant,Probiotics
- From:
Microbiology
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Many microbial pathogens,including those responsible for major enteric infections,exploit oligosaccharides that are displayed on the surface of host cells as receptors for toxins and adhesins. Blocking crucial ligand receptor interactions is therefore a promising therapeutic strategy. One approach is to express molecular mimics of host receptors on the surface of harmless recombinant bacteria that can survive in the gut. These recombinant probiotics bind bacterial toxins in the gut lumen with very high avidity,thereby preventing disease.
