Clinical Differences According to Genotype in Acute Viral Hepatitis A in Daejeon, Korea.
- Author:
Young Woo LEE
1
;
Hyeon Woong YANG
;
Jin A LEE
;
Ki Ho YUN
;
Seong Eun YANG
;
Min Ji LEE
;
Se Young PARK
;
Sae Hee KIM
;
Hyang Ie LEE
;
Yun Jung LEE
;
Sung Hee JUNG
;
An Na KIM
;
Sang Woo CHA
;
Soo Young KIM
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Eulji University College of Medicine, Daejeon, Korea. 20040544@eulji.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatitis A;
Prevalence;
Genotype
- MeSH:
Abdominal Pain;
Alanine Transaminase;
Aspartate Aminotransferases;
Bilirubin;
C-Reactive Protein;
Diarrhea;
Genotype;
Hemoglobins;
Hepatitis;
Hepatitis A;
Hepatitis A Antibodies;
Hospitalization;
Humans;
Immunoglobulin M;
International Normalized Ratio;
Korea;
Occupations;
Perches;
Prevalence;
Prospective Studies;
Real-Time Polymerase Chain Reaction;
Skin;
Vomiting
- From:Korean Journal of Medicine
2011;80(5):553-561
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Acute viral hepatitis A is a major health problem in Korea and the influx of genotype IIIA is thought to be one reason. We examined the differences in the clinical characteristics and laboratory findings of genotypes IA and IIIA in Daejeon. METHODS: From November 2009 to June 2010, 81 patients positive for IgM anti-HAV were enrolled prospectively. The hepatitis A was genotyped using real-time polymerase chain reaction. The clinical characteristics and laboratory results were compared on the basis of genotype. RESULTS: The mean patient age was 32.6 +/- 7.4 years. The mean hospitalization was 7.7 +/- 2.4 days. The patient occupation varied. Clinically, vomiting and diarrhea were relatively more prevalent in genotype IIIA than in IA. Abdominal pain and skin spots were relatively more prevalent in genotype IA than in IIIA. The hemoglobin, peak aspartate aminotransferase (AST) level, and C-reactive protein were statistically higher in genotype IIIA than in IA. The distributions of the peak AST, alanine aminotransferase (ALT) and total bilirubin values tended to be perched in genotype IIIA than in IA. The international normalized ratio (INR) tended to be slightly prolonged in genotype IIIA than in IA. CONCLUSIONS: Recently, genotype IIIA of acute viral hepatitis A has become prevalent in Daejeon. Hepatitis A genotype IIIA probably causes worse laboratory abnormalities than genotype IA.
