The Effect of Combination Treatment of Fosinopril and Losartan on Microalbuminuria in Patients with Essential Hypertension
- VernacularTitle:福辛普利与氯沙坦联用对高血压患者尿微量白蛋白的影响
- Author:
Jing-Wen HUANG
;
Ze-Fu YANG
;
Shao-Jin LUO
;
Shi-Rong XUE
;
Ling YANG
;
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Microalhuminuria;
Fosinopril;
Losartan
- From:
Chinese Journal of Hypertension
2007;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the the effect of microalbuminuria of combined treatment with fosinopril and losartan,or fosinopril,losartan monotherapy in patients with hypertension.Methods In this double-blind, intention to treat study,136 patients with hypertension were randomly assigned to receive fosinopril 10 mg/d(n= 50),losartan 50 mg/d(n=41),or a combination of fosinopril 5 mg and losartan 25 mg (n=45) qd for 4 weeks, followed by titrating to the maximum recommended doses for another 4 weeks.The primary endpoint was the difference of mean sitting blood pressure and microalbuminuria excretion at baseline and week 8.Results At week 8,the combination of fosinopril and losartan therapy lowered mean mieroalbuminuria from baseline by 26.1?10~(-8) mol/L,significantly more than either monotherapy approaches (fosinopril 20 mg,18.3?10~(-8)mol/L,P
