Atorvastatin Decreases TLR4 Expression on Circulating CD_(14)~+ Monocytes in Patients with Acute Coronary Syndromes
- VernacularTitle:阿托伐他汀降低急性冠脉综合征患者外周血CD_(14)~+单核细胞表面TLR4的表达
- Author:
Nan NIU
;
Peng QU
;
Dan XU
;
Ying CUI
;
Yan-Chun DING
;
Hong-Yan WANG
;
Ning ZHU
;
Hai-Ying CHEN
;
- Publication Type:Journal Article
- Keywords:
Acute coronary syndrome;
Atorvastatin;
Monocytes;
Toll-like receptor4
- From:
Chinese Journal of Hypertension
2007;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Previous studies indicated that activation of Toll-like receptor4 (TLR4) was involved in the progression and instability of atherosclerotic plaque.Anti-inflammatory effects were shown in statins. However,the mechanisms underlying these effects have not been well explored.We test the hypothesis that a por- tion of these anti-inflammatory effects are mediated by regulation of TLR4 expression.Methods One hundred twenty-one subjects (22 normal persons,17 patients with stable angina and 82 patients with ACS) were recruited. 41 patients with ACS were randomized to atorvastatin 10 mg/d or atorvastatin 40 mg/d on top of routine anti-anginal treatment.Serum level of hsCRP,blood lipids,TLR4 expression on CD_(14)~+ monocytes were measuered before and after one month treatment.TLR4 expression on CD_(14)~+ monocytes were quantified via flow-cytometry.Results hsCRP and TLR4 expression on CD_(14)~+ monocytes in patients with ACS were higher than patients with stable angina and normal persons(hsCRP,ACS:11.1?14.3 vs stable angina:2.5?2.7 mg/L vs normal:2.3?4.2 mg/L,P
