Heparan Sulfate and Foot-and-mouth Disease Virus Infection
- VernacularTitle:硫酸乙酰肝素与口蹄疫病毒感染
- Author:
Jun-Zheng DU
;
Hui-Yun CHANG
;
Shan-Dian GAO
;
Xue-Peng CAI
;
- Publication Type:Journal Article
- Keywords:
Heparan sulfate,Foot-and-mouth disease virus,Receptors,Host tropism
- From:
Microbiology
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Receptors are primary determinant of viral tropism and disease pathogenesis.Heparan sulfates (HS)are ubiquitous,polyanionic carbohydrate chains linked to core proteins in cell membranes and ex- tracellular matrices of all eukaryotes.HS have also been demonstrated to function as receptors or co-receptors for a number of different viruses.To date,HS and four RGD-dependent integrins,?v?3,?v?6, ?v?1,and?v?8 have been reported to serve as receptors for Foot-and-mouth disease virus(FMDV).Different receptors may be used to interact with host cells during FMDV infection.Studies on the structure and function of receptors are very important for understanding the interaction between host cells and FMDV. Here,We mainly reviews the progress on the biological characteristics of HS and its roles in FMDV infection.
