Molecular Mechanism of Hyaluronan Biosynthesis in Streptococci and Construction of Engineering Strains
- VernacularTitle:链球菌生物合成透明质酸的分子机理与基因工程菌构建进展
- Author:
Ping-Fang TIAN
;
Kai QU
;
Tian-Wei TAN
;
- Publication Type:Journal Article
- Keywords:
Hyaluronic acid Biosynthesis Construction of engineering strain Fermentation
- From:
China Biotechnology
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Hyaluronic acid(HA)is a linear polysaccharide chain composed of alternating ?-1,4-glucuronic acid(GlcA)and ?-1,3-N-acetylglucosamine(GlcNAc)moieties.Construction of engineering strain has become the prevailing strategy for increasing yield and improving its quality,especially the molecular weight.Here the molecular mechanism of HA biosynthesis in Streptococcus strains was reviewed,involving fermentation strains,operon structure,crucial enzyme and construction of engineering strains.In addition,the prevalent problems in HA fermentation production were also discussed and the protocols were tentatively put forward for the upcoming research and industrial production.
