Effects of Found in Inflammatory Zone 1 on The Migration of Vascular Smooth Muscle Cells and The Potential Mecha- nism
- VernacularTitle:FIZZ1促使血管平滑肌细胞迁移的机制
- Author:
Ling-Yun GAO
;
Fu-Ping LI
;
Zuo-Yun HE
;
Jiao MU
;
- Publication Type:Journal Article
- Keywords:
Found in inflammatory zone 1;
Vascular smooth muscle cell;
Migration;
F-actin;
PI3K/Akt
- From:
Chinese Journal of Hypertension
2007;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of found in inflammatory zone 1(FIZZ1) on the migration of cul- tured mouse vascular smooth muscle cell(VSMC) and the potential mechanism.Methods Using Boyden chamber, immunofluorescence and Western blot,the migratory effects,F-actin content and Akt/Akt1 expression were deter- mined in VSMC after stimulation by FIZZ1.Results FIZZ1 markedly increases the migratory ratio,F-actin con- tent and the Akt1 expression of VSMC.Ly294002,a PI3K inhibitor,attenuated migratory ratio,F-actin content and the Akt1 expression of VSMC promoted by FIZZ1 in a dose-dependent manner (10-30 ?mol/L).Conclusion Our data demonstrated FIZZ1 by activating PI3K/Akt1 pathway induced the expression of F-actin of VSMC,and promoted the migration of VSMC.
