Comparative proteomics of the kidney in lupus nephritis mouse
- VernacularTitle:狼疮肾炎小鼠肾脏的比较蛋白质组学
- Author:
Meng-Ru SHI
;
Quan LIN
;
Jian-Xin LV
;
- Publication Type:Journal Article
- Keywords:
lupus nephritis;
systemic lupus erythematosus;
kidney;
proteome;
two dimensional electrophoresis
- From:
Basic & Clinical Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the differential proteome of kidney between lupus nephritis mouse and normal mouse.Methods The proteins of kidney were separated by two-dimensional gel electrophoresis(2-DE).The gels stained by silver were scanned by ImageScanner and analyzed by PDQuest software.Results About 573?52 and 658?43 protein spots were found in the three maps of control group and LN group respectively;the match ratio was 83% and 87% respectively.One hundred and fourteen spots were found increased that showed a two fold increase as comparing to control group.Conclusion A significant difference in protein expression of LN mouse kidney was found and may be related to the pathogenesis of LN.
