The Phosphorylation of Focal Adhesion kinase in The Restenosis of Rat's Vein Graft:Modulation by Olmesartan
- VernacularTitle:大鼠移植静脉再狭窄过程中黏着斑激酶的活化及奥美沙坦的干预作用
- Author:
Ping-Xi XIAO
;
Zhi-Jun LIU
;
Jing-Guo WU
;
Li-Chun WANG
;
Jian-Gui HE
;
Zhao-Hui PEI
;
Hong MA
;
- Publication Type:Journal Article
- Keywords:
Olmesartan;
Restenosis;
Focal adhesion kinase;
Phosphorylation
- From:
Chinese Journal of Hypertension
2007;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and phosphorylation of focal adhesion kinase(FAK) in rat's au- tologous vein graft and the olmesartan modulating effect.Methods Autologous external jugular veins were grafted to common carotid arteries in 40 male Sprague Dawley rats.After surgery,rats were randomly assigned to the fol- lowing groups:sham;control;olmesartan treatment(10mg/kg.d by gavage);or physiological saline.The intimal thickness,the I/M in vein grafts was quantitated by HE stain.The expression and phosphorylation of focal adhe- sion kinase were assessed by Western-blotting,PCNA and ?-smooth muscle actin were measured by immunohisto- chemistry.Results Neointimal hyperplasia in control group was characterized by significantly increased intimal thickeness I/M(P
