Progress in Research on HIV-1 Integrase and Its Inhibitors
- VernacularTitle:HIV-1整合酶及其抑制剂的研究进展
- Author:
Fang-Qiong LI
;
Qian DING
;
Jin-Biao ZHAN
;
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus-1 Integrase Inhibitor RNA interference
- From:
China Biotechnology
2006;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
HIV-1 integrase enzyme is a 32kDa protein encoded by HIV pol gene. It is responsible for integration of viral cDNA into host chromosomal DNA, which is indispensable for HIV replication.Since there was no functional equivalent for this enzyme in human cells, inhibition of integrase will bring little side effect to human body. Thus HIV integrase has become an attractive and rational target for therapy of AIDS after reverse transcriptase and protease.The Recent research on HIV-1integrase structure,inhibitors and new therapeutic method target at HIV integrase was reviewed.
