Effect of Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene on antioxidation activities in mice
- VernacularTitle:转hCu,Zn-SOD突变基因聚球藻抗氧化作用的研究
- Author:
Ren-Hai LIU
;
Shu-Bin GAO
;
Jun ZHANG
;
Hong XU
;
Ke-Fu ZHOU
;
- Publication Type:Journal Article
- Keywords:
Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene;
antioxidation GSH-Px;
CAT;
SOD;
MDA
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the biological activities of Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene.Methods Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD were administered orally for 20d to mice,then the activities of glutathione peroxidase(GSH-Px),catalase(CAT),superoxide dismutase(SOD) and the content of malondialdehyde(MDA) were determined.Results The activities of GSHPx in serum and the activities of CAT in blood increased obviously;the activity of SOD in serum and liver increased markedly;the content of MDA in serum and liver decreased obviously.Conclusion Synechococcus sp.PCC7942 with trans-mutated hCu,Zn-SOD-gene had obvious antioxidant effect in vivo.
