Preparation of aliginic sodium diester liposome and measurement of its size distribution
- VernacularTitle:藻酸双酯钠脂质体的制备及粒度分布的测定
- Author:
Ji-Bo WANG
;
Wang YUE
;
Yan-Zeng SUN
;
Ling-Ling ZHANG
;
Guo-Feng LV
;
- Publication Type:Journal Article
- Keywords:
aliginic sodium diester;
liposome;
preparation;
size distribution
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Aliginic sodium diester(ASD) liposome was prepared and its aggregation stability was evaluated.Methods ASD liposome was made by reverse phase evaporating method from egg yolk lecithin,compared with blank liposome,the size distributions and mean particle diameters of ASD liposome and blank liposome were measured respectively before and after 40 hours heating under 37℃.Results Under the condition of n(PC)∶n(CHOL) = 1∶1,the mean size diameter of ASD liposome was 4.24?m.The mean size diameter of ASD liposome changed only 0.26?m after cultivation,however,the value of blank liposome was 1.35?m.Conclusion ASD loaded in the liposome enhanced the physical stability of the liposome.
