Advances in the Research on the Brucella Intracellular Life
- VernacularTitle:布鲁氏菌胞内生存机制研究进展
- Author:
Yu-Fei WANG
;
Ze-Liang CHEN
;
Liu-Yu HUANG
;
- Publication Type:Journal Article
- Keywords:
Brucella,Bacterial invasion,Intracellular trafficking,Intracellular replication
- From:
Microbiology
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Brucella organisms are facultative intracellular bacteria capable of surviving inside professional and non-professional phagocytes.Upon cell contact the bacteria is internalized via receptor molecules.Once inside cells,Brucella localizes in early phagosomes,where it avoids fusion with late endosomes and lysosomes.Then,the bacterium redirects its trafficking to autophagosomes and finally reaches the endoplasmic reticulum,the replicating niche.Once inside the endoplasmic reticulum,Brucella extensively replicates without restricting basic cellular functions or inducing damage to cells.Invasion,intracellular trafficking and replication of Brucella organisms in professional and non-professional phagocytes and the molecular determinants involving Brucella intracellular life are reviewed in this article.
