Association of some SNP in TGFA,IRF6 and nonsyndromic cleft lip with or without cleft palate by DNA microarray technology
- VernacularTitle:非综合征性唇腭裂与干扰素调节因子6和转化生长因子?单核苷酸多态性的相关性
- Author:
Ya SHEN
;
Lu CHENG
;
Wei-Dong WAN
;
Zu-Hong LU
;
Lian-Ming LIAO
;
Yu-Gui CUI
;
Jia-Yin LIU
;
- Publication Type:Journal Article
- Keywords:
Nonsyndromic cleft lip with or without cleft palate;
Interferons;
Transforming growth factor-?;
Genes;
Polymorphisms,single nucleotide
- From:
Chinese Journal of Laboratory Medicine
2003;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between some single nucleotide polymorphisms (SNP)loci of interferon regulatory factor 6(IRF6)gene,transforming growth faetor-?(TGFA)gene and nonsyndromic cleft lip with or without cleft palate(NSCL/P)in nuclear families consisting of fathers, mothers and affected offspring with NSCL/P from southeast China.Methods Some SNloci of IRF6 and TGFA were detected by applying microarray technology in nuclear families,and then haplotype relative risk (HRR)and transmission disequilibrium test(TDT)were performed.Results There were no significant difference in genotypes and alleles distribution between patients and their parents.The SNP locus——V274I of IRF6 was associated with NSCL/P(HRR:?~2=4.5816,P
