Short-term and long-term outcomes of moxifloxacin treatment in acute exacerbations of COPD
- VernacularTitle:莫西沙星治疗慢性阻塞性肺疾病急性加重的近期和远期疗效观察
- Author:
Min ZHANG
;
Xin ZHOU
;
Xing-Yi ZHANG
;
Xing DING
;
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Exacerbation;
Moxifloxacin
- From:
Chinese Journal of Infection and Chemotherapy
2007;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the aetiology of acute exacerbations of COPD (AECOPD),and the effects of moxifloxacin in the treatment of AECOPD.Methods Patients with stable COPD based on GOLD criteria were included in the study.Sputum collected at first exacerbation was analyzed for bacteria count and culture.IL-6,IL-8 and TNF-?were measured by enzyme- linked immunosorbent assay (ELISA).Eligible patients were randomized to receive moxifloxacin (400 mg qd for 5 days) or ce- faclor (250 mg q8h for 7 days).Efficacy parameters were evaluated at 7 and 14 days after treatment initiation and 1 year later. Results Of the 46 patients with moderate or severe COPD (male 38,moderate 24),21 (45.65%) were microbiologically evalu- able at baseline.The main pathogen was Haemophilus influenzae (10/21).Clinical efficacy rate was 87.0% in moxifloxacin group and 82.6% in cefaclor group.Bacterial eradication rate was 80.0% and 72.7% respectively.The difference between groups was not statistically significant in terms of clinical or microbiological efficacy.In moxifloxacin arm,the frequency of ex- acerbation was 2.6?1.0,significantly lower than control arm (3.5?1.4,P
