Population pharmacokinetics of norvancomycin
- VernacularTitle:去甲万古霉素群体药动学研究
- Author:
Jing ZHANG
;
Ying-Yuan ZHANG
;
Yao-Guo SHI
;
Jian-Zhong RUI
;
Ji-Chen YU
;
Guo-Ying CAO
;
Ju-Fang WU
;
- Publication Type:Journal Article
- Keywords:
Norvancomycin;
Population pharmacokinetics;
Nonlinear mixed effect model;
Therapeutic drug monitoring;
Fluorescence polarization immunoassay
- From:
Chinese Journal of Infection and Chemotherapy
2007;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
85 mL/min),CL=6.0?(WT/60)~(0.52).④The increased volume of peripheral distribution (V_2) was observed when norvancomycin was co-administered with diuretics;④Reduced drug clearance,prolonged t_(1/2),and increased values of AUC_(24) were found in elderly patients.Conclusions Renal function impairment and age have significant impact on PK parameters of norvancomycin.Dosing regimens of norvancomycin were finally established for different patients on the basis of important PPK parameters generated from different groups of patients.