Design of method comparison and bias estimation of multi tests on multi instruments
- VernacularTitle:多台生化分析仪多项目同时进行比对的实验研究设计及应用
- Author:
Ling QIU
;
Xin-Qi CHENG
;
Li LIU
;
Fu-Cheng LIU
;
Qian LIU
;
Zeng-Mei GE
;
- Publication Type:Journal Article
- Keywords:
Evaluation studies;
Reproducibility of results;
Uncertainty
- From:
Chinese Journal of Laboratory Medicine
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To design an experiment for method-comparison and bias estimation of multi tests on multi instruments.Methods According to the procedure described by the NCCLS approved guideline EP9-A and improving the method of sample collection,we took 8 patient mixing samples each day to analyze all comparison tests on 11 auto-chemistry analyzer within following 5 days.The duplicates were assessed within the same run.The coefficient of correlation and average bias% were calculated,and the system errors at medical decided levels were assessed.Results Taking ALT as an example,the coefficients of correlation were between 0.994-1.000,and the average bias% were between-0.460%-4.927%,SE at 40U/L was-1.510-1.834 and SE at 300 U/L was-3.101-9.188.Conclusion In all tests that joined the comparison among the different instruments,28 tests were acceptable,2 tests were acceptable after modifying the coefficients,and AMY and LIP were not acceptable.
