Association of thrombin activatable fibrinolysis inhibitor and its encoding gene CPB2 (Thr325Ile) polymorphism with myocardial infarction
- VernacularTitle:凝血酶激活的纤溶抑制物及其编码基因CPB2(Thr325Ile)多态性与心肌梗死关系的研究
- Author:
Cheng-Wei XU
;
Li-Li WANG
;
Yi-Meng DU
;
Jing-Jie ZHAO
;
Cui-Ying JIANG
;
Xiao-Ben WU
;
- Publication Type:Journal Article
- Keywords:
Thrombin activatable fibrinolysis inhibitor;
Gene;
Myocardial infarction
- From:
Chinese Journal of Laboratory Medicine
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association of thrombin activatable fibrinolysis inhibitor (TAFI)and its encoding gene CPB2 polymorphism with myocardial infarction.Methods CPB2 gene (Thr325Ile)polymorphism were typed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)in patients of myocardial infarction(n=100)and a control group(n=90).The antigen(Ag) and the activity(Act)of TAFI were determined by ELISA and chromogenic assay respectively.The relationship between Thr325Ile gene polymorphism and TAFI Ag and Act were also analyzed.Results In MI group TAFI Ag and Act[TAFI Act(51.4?9.3)?g/ml,TAFI Ag(145.6?33.5)%]were significently higher than those of control group[TAFI Act(25.7?5.6)?g/ml,TAFI Ag(76.5?24.8)%] (t=22.927 2,P
