Quantification of T lymphoma invasion and metastasis inducing factor 1 mRNA and its correlation with gastric cancer biological behaviours
- VernacularTitle:T淋巴瘤侵袭转移诱导因子1表达水平与胃癌生物学行为的关系
- Author:
Bao-Jie GUAN
;
Li-Hua LIU
;
En-Ying ZHANG
;
Wei XU
;
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Tumor metastasis;
T lymphoma invasion and metastasis inducing factor 1
- From:
Chinese Journal of Laboratory Medicine
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression quantity of T lymphoma invasion and metastasis inducing factor 1(Tiara 1)in gastric cancer tissues,tissues around the cancer over 3 cm and tissues of gastric benign lesions,and to analyze the correlation between amount of Tiaml and gastric cancer biological behaviours.Methods Real-time fluorescence quantitive RT-PCR(FQ-RT-PCR)was used to detect the expression level of Tiaml mRNA in 66 cases of gastric cancer tissues,tissues around the cancer over 3 cm and the gastric tissues of 11 cases with benign lesion.Results Positive rate of Tiam1 mRNA expression in gastric cancer tissues,tissues around the cancer was 92.4%,19.7%,respectively,and only one case express Tiaml mRNA in 11 cases gastric benign lesion tissues.There was significant difference(P0.05),on the other hand,the expression quantity of Tiaml mRNA in gastric cancer was significantly correlated with metastasis into lymph node,the extent of invasion,differentiated degree of histologic type,and the stages of TNM(P
