Novel Mutants of Microbial Glycosidases——Generation and Application of Thioglycoligases
- VernacularTitle:微生物糖苷酶的新型突变酶——硫代糖苷酶的产生及应用
- Author:
Li-Li LU
;
Min XIAO
;
Han ZHAO
;
- Publication Type:Journal Article
- Keywords:
Glycosidases, Thioglycoligases, Synthesis
- From:
Microbiology
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Acid/base mutants of glycosidases, namely thioglycoligases, are able to catalyze thioglycosides synthesis. Now, many thioglycoligases, including ?-thioglucoligase, ?-thiomannoligase, ?-thiogalactoligase, ?-thioxyloligase and ?-thioglucoligase, have been developed from bacteria and archaebacteria, and applied in synthesizing various thioglycoligases. Recently, thioglycoligases have been used to glycosylate the glycoprotein and firstly generate the thioglycoprotein. The novel extended synthetic function of glycosidases would promote the development of glycobiology, biotechnology and pharmacy.
