Association of angiotensinogen gene polymorphisms with the risk of essential hypertension in the elderly
- VernacularTitle:血管紧张素原基因多态性与老年原发性高血压发病风险性研究
- Author:
Yi-Yang ZHAN
;
Xiao JIANG
;
Hai-Hui SHENG
;
Gang LIN
;
Hua-Sheng XIAO
;
Jian LI
;
Yun-Lin CHENG
;
Jun HUANG
;
- Publication Type:Journal Article
- Keywords:
Angiotensinogen;
Hypertension;
Gene
- From:
Chinese Journal of Laboratory Medicine
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of angiotensinogen(AGT)gene A-6G、T174M and G-217A polymorphisms with the risk of essential hypertension(EH)in the elderly of Han nationality.Methods Genotypes of AGT gene A-6G,T174M and G-217A polymorphisms in 177 aged EH patients and 86 sex and age-matched controls were analyzed with gene chip technology.Results The A-6G and T174M polymorphisms of AGT gene were significantly associated with EH.The numbers of the three genotypes of A-6G were 113,58 and 6 in the patient group and 70,15 and 1 in the control group(P= 0.014)and those of T174M were 94,77 and 6,60,25 and 1(P=0.031),respectively.G-217A polymorphism was not related to EH.Individuals carrying A-6G AA and T174M CC genotypes showed 57% and 56% lower risk of EH(OR=0.43;95%CI=0.23-0.82 and OR=0.44;95%CI=0.25-0.79, respectively).Conclusions The A-6G AA and the T174M CC genotype may be related with decreased risk of EH and G-217A polymorphism may have little role in the etiology of EH in Han nationality.
