Studies on sLe~(a/x) and Hematogenous Metastasis of Cancer
- VernacularTitle:sLe~(a/x)与肿瘤血源性转移研究进展
- Author:
Yun-Li PENG
;
Jing LI
;
Mei-Yu GENG
;
- Publication Type:Journal Article
- Keywords:
sLe~(a/x) Cancer Hematogenous metastasis Bioactive conformation
- From:
China Biotechnology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The expression of sLea/x which correlates with conventional histopathologic parameters serves as a useful indicator for the prognosis of metastatic disease. The bindings between sLea/x and their common ligand E-selectin initiate hematogenous metastasis of cancer. Certain bioactive conformation is crucial for the interaction between sLea/x and their ligands. Thus, a new class of compounds that mimic the structures of sLea/x can potently inhibit not only their functional bindings to selectins, but also the metastasis of cancer. This review is mainly on the sLea/x molecular structure,biosynthesis,distribution, especially the relationship between sLea/x and hematogenous metastasis of cancer and the design of drugs that mimic the structures of sLea/x.
