pRNA: A Safe,Stable and Large Capacity Molecular Vehicle for Gene Therapy
- VernacularTitle:pRNA:一种安全、稳定、大容量的基因治疗分子载体
- Author:
Feng-Ping XU
;
Jun YANG
;
Xue-Song FENG
;
Li-Jia AN
;
- Publication Type:Journal Article
- Keywords:
pRNA Multiple molecular vehicle Gene therapy Safety
- From:
China Biotechnology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The molecular delivery vectors used in gene therapy need provide the features of safety,stability, efficiency and capacity. The current studies on the structure and action mechanism of pRNA, a packaging RNA of phage?29, showed that pRNA with multiple binding sites can through cell membrane easily and escort exogenous molecules to target cell, without inducing immune reaction. As an ideal nano-scale gene therapy vehicle, pRNA presents a promising application in delivering multiple therapeutic components to detect and treat human diseases.
