The Process of Mesenchymal Stem Cells and their Potential as Cardiac Therapeutics
- VernacularTitle:骨髓间质干细胞修复受损心肌研究进展
- Author:
Shu-Kuan LING
;
Ying-Hui LI
;
Zhong-Quan DAI
;
Fen YANG
;
Jie-Lin NIE
;
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cells Cell transplant Cellular fusion Paracrine effects
- From:
China Biotechnology
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow mesenchymal stem cells (MSCs), multipotent stem cells, can replicate as undifferentiated cells and have the potential to differentiate into different lineages of mesenchymal tissues, including bone, cartilage,endothelial, neural, smooth muscle, skeletal myoblasts, and cardiac myocyte cells. The ischemia-induced death of cardiomyocytes results in scar formation and reduced contractility of the ventricle. Several preclinical and clinical studies have supported the notion that MSCs therapy may be used for cardiac regeneration.When transplanted into the infracted heart, MSCs prevent deleterious remodeling and improve recovery, but the mechanism is not clear. In this work,we review evidence and new prospects that support the use of MSCs in cardiomyoplasty.
